With a regional office in Yaoundé, JRS West Africa has been present in Chad, Central African Republic, Cameroon, Democratic Republic of Congo, and began operations in Nigeria in 2018.

Efforts in this region focus on education, protection, and psychosocial support. The education programmes cover formal education (kindergarten, primary, secondary and post-secondary education), teacher training, and non-formal education, such as adult literacy and vocational training. JRS West Africa is also particularly dedicated to child protection, girls education, and psychosocial support for child soldiers, including reconciliation workshops to foster social cohesion.